TOX Acts an Oncological Role in Mycosis Fungoides
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منابع مشابه
TOX Acts an Oncological Role in Mycosis Fungoides
Mycosis fungoides (MF) is a low-grade lymphoma characterized by clonal expansion of atypical CD4+ skin-homing T lymphocytes. Herein, we examined the role of thymocytes selection associated HMG-box (TOX), a gene previously found to be unregulated in MF skin biopsies, in MF pathogenesis. TOX encodes a high-mobility group family (HMG) domain DNA binding nuclear protein, which regulates the differe...
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Background: Chemokines are a family of cytokines initially characterized by their capacity to induce chemotaxis, or directed leukocyte migrations. These receptors are activated by chemotactic cytokines called chemokines. Interactions between chemokines and chemokine receptors also are involved in tumorigenesis, migration and invasion of lymphoma cells.Methods: An English literature search...
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It is a challenging task to diagnose mycosis fungoides (MF), a type of primary cutaneous lymphoma, in the early stages of its development, due to the unspecific presentations associated with the disease. Histopathology and immunohistochemistry conduce to a more definite diagnosis. Presence of atypical T-cells in epidermis and upper dermis is the most significant pathologic finding. Herein...
متن کامل[Mycosis fungoides].
History A middle-aged male with a 10-year-history of generalized pruritus involving the whole body was seen in a skin clinic. He denied any significant past medical or drug history. He had no known allergy. Previous skin biopsy performed over the abdomen in February 1999 showed features of lichen planus. He was treated with various topical steroids, emollients and antihistamines but the skin ra...
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Ichthyosiform eruption as a specific manifestation of mycosis fungoides is very rare and only a few such cases have currently been reported in the medical literature. A 63-year-old Korean man presented with a 4-year history of a pruritic ichthyotic eruption. There was no personal or family history of ichthyosis or atopy. The ichthyosiform skin changes involved the abdomen, arms, thighs and shin...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0117479